Mesenchymal stem cells as therapeutic agents of inflammatory and autoimmune diseases

Graphical abstract Highlights ► Immunomodulatory properties of MSCs in vitro and in vivo are discussed. ► Safety and efficacy of treatments with allogeneic MSCs are discussed. ► Future directions to improve efficacy of MSC treatments are proposed.

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Bibliographic Details
Published in:	Current opinion in biotechnology Vol. 23; no. 6; pp. 978 - 983
Main Authors:	DelaRosa, Olga, Dalemans, Wilfried, Lombardo, Eleuterio
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-2012
Subjects:	adults animal models Animals autoimmune diseases Autoimmune Diseases - immunology Autoimmune Diseases - therapy Cell Transformation, Neoplastic clinical trials Humans immunomodulators Inflammation - immunology Inflammation - therapy Internal Medicine Mesenchymal Stem Cell Transplantation - adverse effects Mesenchymal Stromal Cells - immunology Mesenchymal Stromal Cells - pathology stem cells stromal cells therapeutics Transplantation, Homologous Treatment Outcome
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Summary:	Graphical abstract Highlights ► Immunomodulatory properties of MSCs in vitro and in vivo are discussed. ► Safety and efficacy of treatments with allogeneic MSCs are discussed. ► Future directions to improve efficacy of MSC treatments are proposed.
Bibliography:	http://dx.doi.org/10.1016/j.copbio.2012.05.005 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0958-1669 1879-0429
DOI:	10.1016/j.copbio.2012.05.005