Mechanical control of integrin-mediated adhesion and signaling

Mechanical control of integrin-mediated adhesion and signaling

Integrin-mediated adhesion is controlled by the number of bonds between cell surface integrins and substrate-bound ligands. Integrin-ligand affinity is modulated by chemical allostery, mechanical allostery and integrin clustering. This review analyzes how each of these factors changes through the ph...

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Bibliographic Details
Published in:Current opinion in cell biology Vol. 24; no. 5; pp. 592 - 599
Main Author: Boettiger, David
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-10-2012
Subjects:
Adhesiveness
Allosteric Regulation
Animals
Cell Adhesion
Cell Membrane - metabolism
Integrins - metabolism
Internal Medicine
Protein Binding
Signal Transduction
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Summary:Integrin-mediated adhesion is controlled by the number of bonds between cell surface integrins and substrate-bound ligands. Integrin-ligand affinity is modulated by chemical allostery, mechanical allostery and integrin clustering. This review analyzes how each of these factors changes through the phases of cell attachment, adhesion strengthening, and clustering. The analysis predicts a dominant role of mechanical factors in both adhesive regulation and integrin signaling for adherent cells. New approaches and experimental analyses will be required to substantiate this hypothesis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2012.07.002