Novel eco-friendly [1,2,4]triazolo[3,4-a]isoquinoline chalcone derivatives efficiency against fungal deterioration of ancient Egyptian mummy cartonnage, Egypt

• Published in: Archives of microbiology Vol. 205; no. 2; p. 57
• Main Authors: Geweely, Neveen S., Soliman, Mona M., Ali, Rania A., Hassaneen, Hamdi M., Abdelhamid, Ismail A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2023; Springer Nature B.V
• Subjects: Acids; Antifungal agents; Antifungal Agents - pharmacology; Antimicrobial agents; Archives & records; Aspergillus flavus; Aspergillus flavus - genetics; Biochemistry; Biomedical and Life Sciences; Biotechnology; Cell Biology; Chalcones; Cultural heritage; Damage detection; Deterioration; Ecology; Efficiency; Egypt; Egyptian civilization; Fungi; Fungicides; Gamma rays; Historic artifacts; Human remains; Isoquinolines; Life Sciences; Metabolites; Microbial Ecology; Microbiology; Microorganisms; Minimum inhibitory concentration; Mummies; Natural products; Original Paper; Skin; Synthesis; VOCs; Volatile organic compounds; Egypt; Mummy; isoquinoline chalcones; triazolo[3,4; Minimum inhibitory concentration; Cartonnage; Microorganism; Archeological objects; Fungal deterioration; triazolo[3,4-a]isoquinoline chalcones
• ISSN: 0302-8933; 1432-072X
• DOI: 10.1007/s00203-022-03395-7

Fungal deterioration is one of the major factors that significantly contribute to mummy cartonnage damage. Isolation and molecular identification of thirteen fungal species contributing to the deterioration of ancient Egyptian mummy cartonnage located in El-Lahun regions, Fayoum government, Egypt was performed. The most dominant deteriorated fungal species are
Aspergillus flavus
(25.70%),
Aspergillus terreus
(16.76%), followed by
A. niger
(13.97%). A newly synthesized series of tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline chalcone derivatives were synthesized and evaluated for their antifungal activities in vitro against the isolated deteriorated fungal species (
Aspergillus flavus, A. niger, A. terreus
,
Athelia bombacina
,
Aureobasidium iranianum
,
Byssochlamys spectabilis
,
Cladosporium cladosporioides
,
C. ramotenellum
,
Penicillium crustosum
,
P. polonicum
,
Talaromyces atroroseus
,
T. minioluteus
and
T. purpureogenus
). The most efficient chalcone derivatives are new chalcone derivative numbers
9
with minimum inhibitory concentration (MIC) ranging from 1 to 3 mg/mL followed by chalcone derivatives number
5
with MIC ranging from 1 to 4 mg/mL.