Post-COVID-19 outcomes of non-dialysis dependent chronic kidney disease patients: a national, multicenter, controlled study

• Published in: International urology and nephrology Vol. 55; no. 2; pp. 399 - 408
• Main Authors: Karadag, Serhat, Ozturk, Savas, Arici, Mustafa, Gorgulu, Numan, Akcali, Esra, Pembegul, Irem, Taymez, Dilek Guven, Kazancioglu, Rumeyza, Ayar, Yavuz, Mutluay, Ruya, Ozdemir, Arzu, Aydin, Zeki, Bashan, Yagmur, Alagoz, Selma, Yilmaz, Fatih, Trabulus, Sinan, Dirim, Ahmet Burak, Ozturk, Ilyas, Inci, Ayca, Azak, Alper, Aktas, Nimet, Kuzu, Tolga, Dheir, Hamad, Basturk, Taner, Ozler, Tuba Elif, Dincer, Mevlut Tamer, Turgutalp, Kenan, Ulu, Sena, Gungor, Ozkan, Bakir, Elif Ari, Odabas, Ali Riza, Seyahi, Nurhan, Yildiz, Alaattin, Ates, Kenan
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-02-2023; Springer Nature B.V
• Subjects: Acute Kidney Injury; Coronaviruses; COVID-19; COVID-19 - complications; Creatinine; Diabetes mellitus; Diabetic nephropathy; Dialysis; Glomerulonephritis; Hemodialysis; Humans; Kidney diseases; Medicine; Medicine & Public Health; Mortality; Nephrology; Nephrology - Original Paper; Nephropathy; Polycystic kidney; Renal Dialysis; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - therapy; Respiration; Respiratory system; Retrospective Studies; Urology; COVID-19; CKD; Outcomes
• ISSN: 1573-2584; 0301-1623; 1573-2584
• DOI: 10.1007/s11255-022-03329-8

Purpose
Coronavirus disease 2019 (COVID-19) has a higher mortality in the presence of chronic kidney disease (CKD). However, there has not been much research in the literature concerning the outcomes of CKD patients in the post-COVID-19 period. We aimed to investigate the outcomes of CKD patients not receiving renal replacement therapy.
Methods
In this multicenter observational study, we included CKD patients with a GFR < 60 ml/min/1.73 m
2
who survived after confirmed COVID-19. Patients with CKD whose kidney disease was due to diabetic nephropathy, polycystic kidney disease and glomerulonephritis were not included in this study. CKD patients with similar characteristics, who did not have COVID-19 were included as the control group.
Results
There were 173 patients in the COVID-19 group and 207 patients in the control group. Most patients (72.8%) were treated as inpatient in the COVID-19 group (intensive care unit hospitalization: 16.7%, acute kidney injury: 54.8%, needing dialysis: 7.9%). While there was no significant difference between the baseline creatinine values of the COVID-19 group and the control group (1.86 and 1.9,
p
 = 0.978, respectively), on the 1st month, creatinine values were significantly higher in the COVID-19 group (2.09 and 1.8, respectively,
p
 = 0.028). Respiratory system symptoms were more common in COVID-19 patients compared to the control group in the 1st month and 3rd month follow-ups (
p
 < 0.001). Mortality at 3 months after the diagnosis of COVID-19 was significantly higher in the COVID-19 group than in the control group (respectively; 5.2% and 1.4%,
p
:0.037). Similarly, the rate of patients requiring dialysis for COVID-19 was significantly higher than the control group (respectively; 8.1% and 3.4%,
p
: 0.045).
Conclusions
In CKD patients, COVID-19 was associated with increased mortality, as well as more deterioration in kidney function and higher need for dialysis in the post-COVID-19 period. These patients also had higher rate of ongoing respiratory symptoms after COVID-19.