Recent advances in modulation of cardiovascular diseases by the gut microbiota

• Published in: Journal of human hypertension Vol. 36; no. 11; pp. 952 - 959
• Main Authors: Masenga, Sepiso K., Hamooya, Benson, Hangoma, Joy, Hayumbu, Valerie, Ertuglu, Lale A., Ishimwe, Jeanne, Rahman, Sharla, Saleem, Mohammad, Laffer, Cheryl L., Elijovich, Fernando, Kirabo, Annet
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-11-2022; Nature Publishing Group
• Subjects: 631/443; 692/699/75; Aging; Antihypertensives; Atherosclerosis; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - etiology; Cardiovascular System; Diabetes; Diet; Digestive system; Epidemiology; Feces; Female; Gastrointestinal diseases; Gastrointestinal Microbiome; Gastrointestinal tract; Health Administration; Humans; Hypertension; Hypertension - etiology; Inflammation; Intestinal microflora; Kidney diseases; Male; Medicine; Medicine & Public Health; Metabolism; Metabolites; Microbiota; Obesity; Pathogenesis; Public Health; Review; Review Article; Risk factors; Salt; Sex differences; Vein & artery diseases
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/s41371-022-00698-6

The gut microbiota has recently gained attention due to its association with cardiovascular health, cancers, gastrointestinal disorders, and non-communicable diseases. One critical question is how the composition of the microbiota contributes to cardiovascular diseases (CVDs). Insightful reviews on the gut microbiota, its metabolites and the mechanisms that underlie its contribution to CVD are limited. Hence, the aim of this review was to describe linkages between the composition of the microbiota and CVD, CVD risk factors such as hypertension, diet, ageing, and sex differences. We have also highlighted potential therapies for improving the composition of the gut microbiota, which may result in better cardiovascular health.