Pre-operative magnetic resonance imaging can predict prostate cancer with risk for positive surgical margins

• Published in: Abdominal radiology (New York) Vol. 47; no. 7; pp. 2486 - 2493
• Main Authors: Quentin, M., Schimmöller, L., Ullrich, T., Valentin, B., Demetrescu, D., Al-Monajjed, R., Mally, D., Esposito, I., Albers, P., Antoch, G., Arsov, C.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-07-2022
• Subjects: Gastroenterology; Hepatology; Imaging; Medicine; Medicine & Public Health; Pelvis; Radiology; Prostatectomy; Staging; Positive surgical margins; Prostate cancer; Predictive biomarker; Prostate MRI
• ISSN: 2366-0058; 2366-004X; 2366-0058
• DOI: 10.1007/s00261-022-03543-z

Purpose
Analysis of patients with pre-operative 3 T multiparametric prostate MRI (mpMRI) to determine reliable MRI-based risk predictors of patients at risk for positive surgical margins (PSM) in robotic assisted radical prostatectomy (RPE).
Methods
Consecutive patients with 3 T mpMRI and subsequent RPE from 01/2015 to 12/2018 were retrospectively included. Patients were compared regarding clinical and MRI related parameters such as length of capsular tumor contact (LCC) and distance to the membranous urethra (UD).
Results
Forty-nine of 179 patients (27%) had PSM in 70 different localizations, with the majority located at the capsule (57%, 40/70), mostly apical and/or posterior. The second most often PSM occurred at the apical urethra (22%, 15/70). PCA was visible on mpMRI at the localization of PSM in 93% at the capsule and in 80% at the urethra. PSA, PI-RADS classification, extraprostatic extension (EPE), and seminal vesicles infiltration (SVI) on MRI were significantly higher / more frequent in patients with PSM. LCC (AUC 0.710), EPE (AUC 0.693), and UD (1-AUC 0.673) predicted PSM (overall). An UD of ≤ 3.5 mm showed the highest accuracy of 95% (J = 0.946) for PSM at the urethra and a LCC of ≥ 22.5 mm with 77% (
J
 = 0.378) for PSM at the capsule.
Conclusion
PSM occurred mostly in the apex and/or posteriorly at the capsule or at the apical urethra. LCC was the best MRI predictor for PSM at the capsule and UD for tumors with PSM at the apical urethra. Using these MRI parameters readers might pre-operatively determine PCA localizations at risk for PSM.