The interplay between non-coding RNAs and Twist1 signaling contribute to human disorders

• Published in: Biomedicine & pharmacotherapy Vol. 135; p. 111220
• Main Authors: Ghafouri-Fard, Soudeh, Abak, Atefe, Bahroudi, Zahra, Shoorei, Hamed, Abbas Raza, Sayed Haidar, Taheri, Mohammad
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-03-2021; Elsevier
• Subjects: Cancer; lncRNA; miRNA; Twist1; miRNA; lncRNA; Twist1; Cancer
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2021.111220

•Twist1 has a fundamental effect in the normal development and in the pathogenesis of human diseases especially cancer.•Twist1 has interactions with some long non-coding RNAs and miRNAs.•TP73-AS1, LINC01638, ATB, NONHSAT101069, CASC15, H19, PVT1, LINC00339, LINC01385, TANAR, SNHG5, DANCR, CHRF and TUG1 interact with Twist1.
Twist-related protein 1 (Twist1) is a basic helix-loop-helix (bHLH) transcription factor (TF) being coded by the TWIST1 gene. This TF has a fundamental effect on the normal development and in the pathogenesis of various diseases especially cancer. Twist1 has interactions with some long non-coding RNAs and miRNAs. The interactions between this TF and various miRNAs such as miR-16, miR-26b-5p, miR-1271, miR-539, miR-214, miR-200b/c, miR-335, miR-10b, and miR-381 are implicated in the carcinogenic processes. TP73-AS1, LINC01638, ATB, NONHSAT101069, CASC15, H19, PVT1, LINC00339, LINC01385, TANAR, SNHG5, DANCR, CHRF, and TUG1 are among long non-coding RNAs which interact with Twist1 and participate in the carcinogenesis. This review aims at depicting the interaction between these non-coding transcripts and Twist1 and the consequence of these interactions in human neoplasms.