LaDIVA: A neurocomputational model providing laryngeal motor control for speech acquisition and production

• Published in: PLoS computational biology Vol. 18; no. 6; p. e1010159
• Main Authors: Weerathunge, Hasini R, Alzamendi, Gabriel A, Cler, Gabriel J, Guenther, Frank H, Stepp, Cara E, Zañartu, Matías
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01-06-2022; Public Library of Science (PLoS)
• Subjects: Adult; Biology and Life Sciences; Computer and Information Sciences; Engineering and Technology; Feedback, Sensory; Humans; Laryngeal Muscles - physiology; Medicine and Health Sciences; Physical Sciences; Social Sciences; Speech - physiology; Speech Perception - physiology; Voice - physiology
• ISSN: 1553-7358; 1553-734X; 1553-7358
• DOI: 10.1371/journal.pcbi.1010159

Many voice disorders are the result of intricate neural and/or biomechanical impairments that are poorly understood. The limited knowledge of their etiological and pathophysiological mechanisms hampers effective clinical management. Behavioral studies have been used concurrently with computational models to better understand typical and pathological laryngeal motor control. Thus far, however, a unified computational framework that quantitatively integrates physiologically relevant models of phonation with the neural control of speech has not been developed. Here, we introduce LaDIVA, a novel neurocomputational model with physiologically based laryngeal motor control. We combined the DIVA model (an established neural network model of speech motor control) with the extended body-cover model (a physics-based vocal fold model). The resulting integrated model, LaDIVA, was validated by comparing its model simulations with behavioral responses to perturbations of auditory vocal fundamental frequency (fo) feedback in adults with typical speech. LaDIVA demonstrated capability to simulate different modes of laryngeal motor control, ranging from short-term (i.e., reflexive) and long-term (i.e., adaptive) auditory feedback paradigms, to generating prosodic contours in speech. Simulations showed that LaDIVA's laryngeal motor control displays properties of motor equivalence, i.e., LaDIVA could robustly generate compensatory responses to reflexive vocal fo perturbations with varying initial laryngeal muscle activation levels leading to the same output. The model can also generate prosodic contours for studying laryngeal motor control in running speech. LaDIVA can expand the understanding of the physiology of human phonation to enable, for the first time, the investigation of causal effects of neural motor control in the fine structure of the vocal signal.