Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines

Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines

Tissue cross-talk is emerging as a determinant way to coordinate the different organs implicated in glucose homeostasis. Among the inter-organ communication factors, muscle-secreted myokines can modulate the function and survival of pancreatic beta-cells. Using primary human myotubes from soleus, va...

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Published in:Scientific reports Vol. 8; no. 1; pp. 10072 - 10
Main Authors: Rutti, Sabine, Dusaulcy, Rodolphe, Hansen, Jakob S., Howald, Cédric, Dermitzakis, Emmanouil T., Pedersen, Bente K., Pinget, Michel, Plomgaard, Peter, Bouzakri, Karim
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 03-07-2018
Nature Publishing Group
Subjects:
13
13/2
13/21
13/95
38/79
38/91
631/443
692/163
96/106
96/21
Angiogenin
Beta cells
Cytokines
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Glucose
Homeostasis
Humanities and Social Sciences
Inflammation
Insulin
Insulin secretion
mRNA
multidisciplinary
Muscles
Myotubes
Osteoprotegerin
Pancreas
Science
Science (multidisciplinary)
Tumor necrosis factor-α
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Abstract Tissue cross-talk is emerging as a determinant way to coordinate the different organs implicated in glucose homeostasis. Among the inter-organ communication factors, muscle-secreted myokines can modulate the function and survival of pancreatic beta-cells. Using primary human myotubes from soleus, vastus lateralis and triceps brachii muscles, we report here that the impact of myokines on beta-cells depends on fiber types and their metabolic status. We show that Type I and type II primary myotubes present specific mRNA and myokine signatures as well as a different sensitivity to TNF-alpha induced insulin resistance. Finally, we show that angiogenin and osteoprotegerin are triceps specific myokines with beta-cell protective actions against proinflammatory cytokines. These results suggest that type I and type II muscles could impact insulin secretion and beta-cell mass differentially in type 2 diabetes through specific myokines secretion.
AbstractList Tissue cross-talk is emerging as a determinant way to coordinate the different organs implicated in glucose homeostasis. Among the inter-organ communication factors, muscle-secreted myokines can modulate the function and survival of pancreatic beta-cells. Using primary human myotubes from soleus, vastus lateralis and triceps brachii muscles, we report here that the impact of myokines on beta-cells depends on fiber types and their metabolic status. We show that Type I and type II primary myotubes present specific mRNA and myokine signatures as well as a different sensitivity to TNF-alpha induced insulin resistance. Finally, we show that angiogenin and osteoprotegerin are triceps specific myokines with beta-cell protective actions against proinflammatory cytokines. These results suggest that type I and type II muscles could impact insulin secretion and beta-cell mass differentially in type 2 diabetes through specific myokines secretion.
ArticleNumber 10072
Author Rutti, Sabine
Hansen, Jakob S.
Pedersen, Bente K.
Pinget, Michel
Bouzakri, Karim
Dusaulcy, Rodolphe
Dermitzakis, Emmanouil T.
Plomgaard, Peter
Howald, Cédric
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/29968746$$D View this record in MEDLINE/PubMed
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Snippet Tissue cross-talk is emerging as a determinant way to coordinate the different organs implicated in glucose homeostasis. Among the inter-organ communication...
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SubjectTerms 13
13/2
13/21
13/95
38/79
38/91
631/443
692/163
96/106
96/21
Angiogenin
Beta cells
Cytokines
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Glucose
Homeostasis
Humanities and Social Sciences
Inflammation
Insulin
Insulin secretion
mRNA
multidisciplinary
Muscles
Myotubes
Osteoprotegerin
Pancreas
Science
Science (multidisciplinary)
Tumor necrosis factor-α
Title Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines
URI https://link.springer.com/article/10.1038/s41598-018-28117-2
https://www.ncbi.nlm.nih.gov/pubmed/29968746
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https://search.proquest.com/docview/2063710393
https://pubmed.ncbi.nlm.nih.gov/PMC6030123
Volume 8
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