Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines

• Published in: Scientific reports Vol. 8; no. 1; pp. 10072 - 10
• Main Authors: Rutti, Sabine, Dusaulcy, Rodolphe, Hansen, Jakob S., Howald, Cédric, Dermitzakis, Emmanouil T., Pedersen, Bente K., Pinget, Michel, Plomgaard, Peter, Bouzakri, Karim
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03-07-2018; Nature Publishing Group
• Subjects: 13; 13/2; 13/21; 13/95; 38/79; 38/91; 631/443; 692/163; 96/106; 96/21; Angiogenin; Beta cells; Cytokines; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Glucose; Homeostasis; Humanities and Social Sciences; Inflammation; Insulin; Insulin secretion; mRNA; multidisciplinary; Muscles; Myotubes; Osteoprotegerin; Pancreas; Science; Science (multidisciplinary); Tumor necrosis factor-α
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-28117-2

Tissue cross-talk is emerging as a determinant way to coordinate the different organs implicated in glucose homeostasis. Among the inter-organ communication factors, muscle-secreted myokines can modulate the function and survival of pancreatic beta-cells. Using primary human myotubes from soleus, vastus lateralis and triceps brachii muscles, we report here that the impact of myokines on beta-cells depends on fiber types and their metabolic status. We show that Type I and type II primary myotubes present specific mRNA and myokine signatures as well as a different sensitivity to TNF-alpha induced insulin resistance. Finally, we show that angiogenin and osteoprotegerin are triceps specific myokines with beta-cell protective actions against proinflammatory cytokines. These results suggest that type I and type II muscles could impact insulin secretion and beta-cell mass differentially in type 2 diabetes through specific myokines secretion.