Effect of intravitreal or sub-tenon triamcinolone acetonide injection at completion of vitrectomy on peripheral retinochoroidal thickness in eyes with proliferative diabetic retinopathy

• Published in: Scientific reports Vol. 9; no. 1; p. 171
• Main Authors: Fujiwara, Yoshito, Iwase, Takeshi, Yamamoto, Kentaro, Ueno, Yoshitaka, Ra, Eimei, Terasaki, Hiroko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17-01-2019; Nature Publishing Group
• Subjects: 692/308/409; 692/700/1421/1846; Administration, Ophthalmic; Adult; Aged; Burns; Diabetes; Diabetes mellitus; Diabetic retinopathy; Diabetic Retinopathy - therapy; Eye - drug effects; Eye - pathology; Female; Humanities and Social Sciences; Humans; Injection; Intravitreal Injections - methods; Male; Middle Aged; multidisciplinary; Retina; Retinopathy; Retrospective Studies; Science; Science (multidisciplinary); Surgery; Triamcinolone acetonide; Triamcinolone Acetonide - pharmacology; Vitrectomy - methods
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-37220-3

The effect of triamcinolone acetonide (TA) on the peripheral retinochoroidal thickness was determined after pars plana vitrectomy (PPV) with scatter photocoagulation in eyes with proliferative diabetic retinopathy. The peripheral retinochoroidal thickness was measured at 5 mm from the limbus in the four quadrants using anterior segment optical coherence tomography before, and 3 days, and 1 and 2 weeks after the surgery. The total peripheral thickness was significantly thicker than the baseline thickness after PPV alone (
P
 < 0.001; 18 eyes), PPV combined with intravitreal TA injection (IVTA;
P
 = 0.011; 19 eyes), and PPV combined with sub-tenon TA injection (STTA;
P
 = 0001; 23 eyes). The total peripheral thickness in the PPV group at 3 days after surgery was significantly thicker than that of the PPV + IVTA (
P
 = 0.015) and of the PPV + STTA groups (
P
 = 0.016). Multiple linear regression analyses showed that the injection of TA by the two routes and the number of photocoagulation burns were significantly correlated with the total peripheral thicknesses at 3 days after the surgery. The results indicate that the PPV with large number of intraoperative scatter photocoagulation burns caused an increase in the total peripheral thickness and an administration of either IVTA and STTA can reduced the degree of thickening.