Spectrum of Pituitary disorders: A retrospective study from Basrah, Iraq [version 2; peer review: 2 approved]

• Published in: F1000 research Vol. 7; p. 430
• Main Authors: Mansour, Abbas Ali, Alhamza, Ali Hussain Ali, Almomin, Ammar Mohammed Saeed Abdullah, Zaboon, Ibrahim Abbood, Alibrahim, Nassar Taha Yaseen, Hussein, Rudha Naser, Kadhim, Muayad Baheer, Alidrisi, Haider Ayad Yassin, Nwayyir, Hussein Ali, Mohammed, Adel Gassab, Al-Waeli, Dheyaa Kadhim, Hussein, Ibrahim Hani
• Format: Journal Article
• Language: English
• Published: England Faculty of 1000 Ltd 2018; F1000 Research Limited; F1000 Research Ltd
• Subjects: Adenoma; Bias; Copyright; Data analysis; Data processing; Diabetes; Diabetes mellitus; Growth hormones; Magnetic resonance imaging; Medical referrals; Metabolism; Patients; Pituitary; Pituitary gland; Prolactin; Surgery; Tumors; Womens health; Iraq; epidemiology; pituitary disease; pituitary adenoma; classification; Sellar and parasellar region lesions
• ISSN: 2046-1402; 2046-1402
• DOI: 10.12688/f1000research.13632.2

Background: Pituitary disorders spectrum includes a wide variety of diseases.This study aimed at a comprehensive description of such disorders for patients from  Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC) in Basrah (Southern Iraq).
Methods: Retrospective data analysis of FDEMC for the period from January 2012 through June 2017. We included all patients with pituitary disorders who have MRI pituitary.
Results: The pituitary disorders were more common among women. Those with macroadenoma were older than those with microadenoma with nearly equal gender prevalence of macroadenoma. Pituitary adenoma constituted the bulk of pituitary disorders in this registry (67.2%). Growth hormone secreting adenoma were the commonest adenoma seen in 41.0% followed by clinically non-functioning pituitary adenoma(NFPA)in 31.4% and prolactinoma in 26.9%. About 64.8% of pituitary adenoma was macroadenoma. Macroadenoma was seen in 73.4 % of growth hormone secreting adenoma, 61.2% in NFPA and 62.0% of prolactinoma (of them six were giant prolactinoma)
Conclusion: Pituitary adenoma constituted the bulk of pituitary disorders in Basrah, growth hormone secreting adenoma is the commonest adenoma followed by NFPA and prolactinoma due to referral bias. A change  in  practice of pituitary adenoma treatment is needed.