Experimental mesangioproliferative glomerulonephritis in rats induced by intravenous administration of anti-thymocyte serum

Focal glomerulonephritis was induced in rats, by a single intravenous injection of anti-Thy-1.1 antibody (ATS). One hour after the administration, the glomeruli of affected rats developed necrotic changes of the mesangial cells while after two hours, mesangiolytic changes appeared. From six days onw...

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Bibliographic Details
Published in:	Acta pathologica japonica Vol. 36; no. 8; p. 1191
Main Authors:	Ishizaki, M, Masuda, Y, Fukuda, Y, Sugisaki, Y, Yamanaka, N, Masugi, Y
Format:	Journal Article
Language:	English
Published:	Australia 01-08-1986
Subjects:	Animals Glomerulonephritis - etiology Glomerulonephritis - pathology Immune Sera - immunology Immunologic Techniques Injections, Intravenous Male Microscopy, Electron Rats Rats, Inbred Strains T-Lymphocytes - immunology
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Summary:	Focal glomerulonephritis was induced in rats, by a single intravenous injection of anti-Thy-1.1 antibody (ATS). One hour after the administration, the glomeruli of affected rats developed necrotic changes of the mesangial cells while after two hours, mesangiolytic changes appeared. From six days onwards, focal segmental mesangial proliferation which persisted until 30 days, occurred. This is thought to be the first report of experimental nephritis induced by pure anti-mesangial antibody.
ISSN:	0001-6632
DOI:	10.1111/j.1440-1827.1986.tb02839.x