Effect of 4-Hexylresorcinol on the Efficiency of Antibiotic Treatment of Experimental Sepsis Caused by Antibiotic-Resistant Klebsiella pneumoniae Strain in Mice

• Published in: Bulletin of experimental biology and medicine Vol. 171; no. 4; pp. 458 - 460
• Main Authors: Shemyakin, I. G., Manzenyuk, O. Yu, El’-Registan, G. I., Firstova, V. V., Kombarova, T. I., Gneusheva, T. Yu, Kyazimov, E. I., Nikolaev, Yu. A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-08-2021; Springer; Springer Nature B.V
• Subjects: Analysis; Animals; Animals, Outbred Strains; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotic resistance; Antibiotics; Bacterial pneumonia; Biomedical and Life Sciences; Biomedicine; Cell Biology; Comparative analysis; Disease Models, Animal; Drug resistance; Drug resistance in microorganisms; Drug Resistance, Multiple, Bacterial - drug effects; Drug Synergism; Drug therapy; Efficiency; Female; Hexylresorcinol - pharmacology; Internal Medicine; Klebsiella Infections - complications; Klebsiella Infections - drug therapy; Klebsiella Infections - pathology; Klebsiella pneumoniae; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - pathogenicity; Laboratory Medicine; Mice; Microbial Sensitivity Tests; Pathology; Pneumonia; Polymyxin B; Polymyxin B - pharmacology; Polymyxin B - therapeutic use; Polymyxins - analogs & derivatives; Polymyxins - pharmacology; Polymyxins - therapeutic use; Sepsis; Sepsis - drug therapy; Sepsis - microbiology; Virulence (Microbiology); polymyxin; Klebsiella pneumoniae Pm; sanified mice; antibiotic resistance; 4-hexylresorcinol; Klebsiella pneumoniae Pmr
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-021-05249-6

High efficiency of a combined preparation including synergistic polymyxin B and 4-hexylresorcinol was shown for treatment of experimental sepsis caused by an antibiotic-resistant highly virulent hypermucoid
Klebsiella pneumoniae
strain KPM9Pm
r
in mice. Complex therapy with polymyxin B (1 mg/kg) and 4-hexylresorcinol (30 mg/kg) led to cure in 80%; in 20% of these mice, no bacterial cells were found. After treatment with polymyxin B alone, only 50% animals survived and all of them contained bacterial cells. Comparative analysis of the results of monotherapy and combined treatment indicates that 4-hexylresorcinol not only increases the efficiency of antibiotic, but also minimizes persistence of the infection agent and therefore, the risk of development of antibiotic resistance.