Effect of tolvaptan on hyponatremia in a dog with syndrome of inappropriate secretion of antidiuretic hormone

• Published in: Journal of Veterinary Medical Science Vol. 85; no. 10; pp. 1047 - 1051
• Main Authors: YAMAMOTO, Hiroka, KIMURA, Kyoga, HORIKIRIZONO, Hiro, TAMURA, Yojiro, KAMBAYASHI, Satoshi, BABA, Kenji, OKUDA, Masaru, MIZUNO, Takuya, IGASE, Masaya
• Format: Journal Article
• Language: English
• Published: Tokyo JAPANESE SOCIETY OF VETERINARY SCIENCE 2023; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Antidiuretics; Clinical Pathology; congenital hydrocephalus; dog; Hydrocephalus; Hyponatremia; Hypothyroidism; Magnetic resonance imaging; Polydipsia; Polyuria; Secretion; syndrome of inappropriate secretion of antidiuretic hormone; tolvaptan; Urinalysis; Vasopressin; Ventricle (lateral)
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.23-0243

A 1-year-old spayed female Miniature Schnauzer had chronic hyponatremia, accompanied by polyuria and polydipsia. Blood tests and urinalysis revealed severe hyponatremia, low plasma osmolality with euvolemia, and increased sodium excretion in urine. Hypothyroidism and hypoadrenocorticism were ruled out as causes. These findings led to the diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Magnetic resonance imaging (MRI) showed dilation of the lateral ventricles, indicating severe hydrocephalus. Tolvaptan, a vasopressin V2 receptor antagonist commonly used in human SIADH, was administered along with water restriction. This treatment resulted in a consistent increase in plasma sodium levels without any adverse effects. This case report represents the first documented evidence of the therapeutic efficacy of tolvaptan in treating SIADH in a dog.