Invasive Aspergillus Laryngotracheobronchitis in an Adult with Primary CNS Lymphoma

Invasive aspergillosis can be difficult to diagnose, and early recognition and initiation of therapy is imperative for improving patient outcomes. A case of invasive Aspergillus laryngotracheobronchitis is presented here with a review of the relevant literature. A 58-year-old male undergoing treatme...

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Bibliographic Details
Published in:	Mycopathologia (1975) Vol. 182; no. 7-8; pp. 733 - 737
Main Authors:	Barry, Mark E., Thomas, William Walsh, Song, Buer, Mirza, Natasha
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-08-2017 Springer Springer Nature B.V
Subjects:	Antifungal agents Aspergillosis Aspergillosis - diagnosis Aspergillosis - microbiology Aspergillosis - pathology Aspergillus - isolation & purification Biomedical and Life Sciences Bronchus Central nervous system Central Nervous System Neoplasms - complications Croup Eukaryotic Microbiology Extubation Fungal infections Humans Immunocompromised hosts Intubation Invasive Fungal Infections - diagnosis Invasive Fungal Infections - microbiology Invasive Fungal Infections - pathology Invasiveness Laryngotracheobronchitis Larynx Life Sciences Lymphoma Lymphoma - complications Lymphomas Male Medical Microbiology Medical schools Microbial Ecology Microbiology Middle Aged Mycoses Neutropenia Plant Sciences Plaques Respiratory Tract Infections - complications Sepsis Trachea Ulcers Larynx Laryngotracheobronchitis Hoarseness Aspergillosis
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Summary:	Invasive aspergillosis can be difficult to diagnose, and early recognition and initiation of therapy is imperative for improving patient outcomes. A case of invasive Aspergillus laryngotracheobronchitis is presented here with a review of the relevant literature. A 58-year-old male undergoing treatment for CNS lymphoma presented with neutropenic sepsis and acute respiratory distress requiring intubation. Following extubation, he reported persistent hoarseness for 1-month duration and he was found to have pseudomembranous plaques and ulcers of the larynx, trachea, and right mainstem bronchus consistent with Aspergillus laryngotracheobronchitis. Invasive Aspergillus laryngotracheobronchitis should be considered in immunocompromised patients presenting with persistent hoarseness.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0301-486X 1573-0832
DOI:	10.1007/s11046-017-0123-y