Effects of Bone Marrow Autotransplantation on the Bone Marrow Neurotransmitter Structures

• Published in: Bulletin of experimental biology and medicine Vol. 167; no. 5; pp. 689 - 693
• Main Authors: Vorob’yova, O. V., Lyubovtseva, L. A., Guryanova, E. A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-09-2019; Springer
• Subjects: 60 APPLIED LIFE SCIENCES; Analysis; Animals; Autografts; Biomedical and Life Sciences; Biomedicine; BONE MARROW; Bone Marrow - immunology; Bone Marrow - metabolism; Bone Marrow Cells - cytology; Bone Marrow Cells - immunology; Bone Marrow Cells - metabolism; Bone Marrow Transplantation; CATECHOLAMINES; Catecholamines - metabolism; Cell Biology; Cell Count; CELL PROLIFERATION; Ethylenediaminetetraacetic acid; FLUORESCENCE; Immunohistochemistry; Internal Medicine; Laboratory Medicine; Male; MAST CELLS; Mast Cells - cytology; Mast Cells - immunology; Mast Cells - metabolism; MICE; Microscopy, Fluorescence; Morphology and Pathomorphology; Neurotransmitter Agents - metabolism; PATHOGENESIS; Pathology; SEROTONIN; Serotonin - metabolism; Transplantation, Autologous; VEINS; granular fluorescent cells; catecholamines; serotonin; mast cells; bone marrow
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-019-04600-2

Morphological structures involved in local regulation of tissue processes and the neurotransmitters they produce are assumed to play an important role in the pathogenesis of oncological diseases. We studied the dynamics of neurotransmitter cell counts and distribution of catecholamines and serotonin in them and analyzed proliferative activity of hemopoietic cells in the bone marrow of mice after bone marrow autotransplantation. The bone marrow of male mice was studied by fluorescent and immunohistochemical methods after injection of the bone marrow from the same mouse into the caudal vein. The count of neurotransmitter cells and the cell proliferation index increased after bone marrow autotransplantation.