Adenylate Cyclase-Associated Protein 1 and Cofilin in Progression of Non-Small Cell Lung Cancer

• Published in: Bulletin of experimental biology and medicine Vol. 167; no. 3; pp. 393 - 395
• Main Authors: Kolegova, E. S., Kakurina, G. V., Kondakova, I. V., Dobrodeev, A. Yu, Kostromitskii, D. N., Zhuikova, L. D.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-07-2019; Springer; Springer Nature B.V
• Subjects: Adenylate cyclase; Biomedical and Life Sciences; Biomedicine; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Cell Biology; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cofilin; Cofilin 1 - genetics; Cofilin 1 - metabolism; Cytoskeletal Proteins - genetics; Cytoskeletal Proteins - metabolism; Ethylenediaminetetraacetic acid; Female; Gene expression; Humans; Internal Medicine; Laboratory Medicine; Lung cancer; Lung cancer, Non-small cell; Lung cancer, Small cell; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Metastases; Metastasis; mRNA; Neoplasm Metastasis - pathology; Non-small cell lung carcinoma; Pathology; Proteins; RNA; RNA, Messenger - biosynthesis; adenylate cyclase-associated protein 1 (CAP1); tumor proliferation; cofilin; non-small cell lung cancer (NSCLC)
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-019-04534-9

We studied the expression of mRNA and the level of CAP1 (adenylate cyclase-associated protein 1) and cofilin proteins in the tissues of patients with non-small cell lung cancer. The expression of mRNA and the level of CAP1 in tumor tissue increased during growth of the primary tumor and its metastasis. It was shown that with the growth of the primary tumor, the content of cofilin in the tumor tissue decreases against the background of increased expression of its mRNA; in regional metastasis, the content of cofilin and expression of the corresponding mRNA increased. It was found that increased content of the studied proteins in the tumor tissue increased the risk of metastasis.