Functional significance of histone deacetylase diversity

Nucleocytoplasmic shuttling of histone deacetylases is emerging as a major step in determining the composition, and hence the activity, of the corresponding nuclear regulatory complexes. This shuttling process is one of the distinctive characteristics of these enzymes, themselves belonging to struct...

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Bibliographic Details
Published in:	Current Opinion in Genetics & Development Vol. 11; no. 2; pp. 162 - 166
Main Authors:	Khochbin, Saadi, Verdel, André, Lemercier, Claudie, Seigneurin-Berny, Daphné
Format:	Book Review Journal Article
Language:	English
Published:	England Elsevier Ltd 01-04-2001 Elsevier
Subjects:	Animals Biochemistry, Molecular Biology Cell Nucleus Cell Nucleus - enzymology chromatin Cytoplasm Cytoplasm - enzymology Histone Deacetylases Histone Deacetylases - chemistry Histone Deacetylases - classification Histone Deacetylases - metabolism Histones Histones - metabolism Humans Life Sciences nucleocytoplasmic shutting silencing transcription transport transcription nucleocytoplasmic shutting Cell biology Genetics Evolution Biochemistry Cancer Biology transport chromatin silencing Structural biology
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Summary:	Nucleocytoplasmic shuttling of histone deacetylases is emerging as a major step in determining the composition, and hence the activity, of the corresponding nuclear regulatory complexes. This shuttling process is one of the distinctive characteristics of these enzymes, themselves belonging to structurally and functionally different classes. Considering the specific features of each class of deacetylases, it is possible to determine how each member can contribute to particular cellular functions.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0959-437X 1879-0380
DOI:	10.1016/S0959-437X(00)00174-X