Blood Microbiota Profile Is Associated with the Responsiveness of Postprandial Lipemia to Platycodi radix Beverage: A Randomized Controlled Trial in Healthy Subjects

• Published in: Nutrients Vol. 15; no. 14; p. 3267
• Main Authors: Kang, Seunghee, Lee, Inhye, Park, Soo-Yeon, Kim, Ji Yeon, Kim, Youjin, Choe, Jeong-Sook, Kwon, Oran
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24-07-2023; MDPI
• Subjects: association; blood microbiota profile; Clinical trials; Discriminant analysis; Feces; Food; Hypotheses; Insulin; Lipoproteins; Metabolism; Microbiota; oral fat load; Plasma; Platycodi radix; postprandial hyperlipemia; responsiveness; United States > US; South Korea; postprandial hyperlipemia; blood microbiota profile; association; Platycodi radix; oral fat load; responsiveness
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15143267

Prolonged postprandial hyperlipidemia may cause the development of cardiovascular diseases. This study explored whether postprandial triglyceride-rich lipoprotein (TRL) clearance responsiveness to
beverage (PR) is associated with changes in blood microbiota profiles. We conducted an 8-week randomized controlled clinical trial involving normolipidemic adults with low fruit and vegetable intakes. Participants underwent an oral fat tolerance test and 16S amplicon sequencing analysis of blood microbiota. Using the Qualitative Interaction Trees, we identified responders as those with higher baseline dietary fat intake (>38.5 g/day) and lipoprotein lipase levels (>150.6 ng/mL), who showed significant reductions in AUC for triglyceride (TG) and chylomicron-TG after the oral fat tolerance test. The LEfSe analysis showed differentially abundant blood microbiota between responders and non-responders. A penalized logistic regression algorithm was employed to predict the responsiveness to intervention on the TRL clearance based on the background characteristics, including the blood microbiome. Our findings suggest that PR intake can modulate postprandial TRL clearance in adults consuming higher fat intake over 38.5 g/day and low fruit and vegetable intake through shared links to systemic microbial signatures.