Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Myocardial Triglyceride Content and Improves Myocardial Function

• Published in: Journal of the American College of Cardiology Vol. 52; no. 12; pp. 1006 - 1012
• Main Authors: Hammer, Sebastiaan, MSc, Snel, Marieke, MD, Lamb, Hildo J., MD, PhD, Jazet, Ingrid M., MD, PhD, van der Meer, Rutger W., MD, Pijl, Hanno, MD, PhD, Meinders, Edo A., MD, PhD, Romijn, Johannes A., MD, PhD, de Roos, Albert, MD, PhD, Smit, Johannes W.A., MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16-09-2008; Elsevier Limited
• Subjects: Caloric Restriction; Cardiology; Cardiovascular; cardiovascular imaging; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diet therapy; Diabetes Mellitus, Type 2 - metabolism; Diastole; Female; Humans; Internal Medicine; Liver - metabolism; Magnetic Resonance Spectroscopy; Male; Middle Aged; Myocardium - metabolism; Obesity; Obesity - complications; Obesity - diet therapy; Obesity - metabolism; Rodents; Spectrum analysis; Systole; triglycerides; Triglycerides - metabolism; type 2 diabetes mellitus; Ventricular Function, Left; Weight control; weight loss; triglyceride; nonesterified fatty acids; T2DM; magnetic resonance; 1HMRS; MR; body mass index; weight loss; ECG; fatty acid; LV; triglycerides; proton magnetic resonance spectroscopy; very-low-calorie diet; electrocardiogram; TG; NEFA; type 2 diabetes mellitus; cardiovascular imaging; FA; left ventricular; BMI; VLCD
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2008.04.068

Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Myocardial Triglyceride Content and Improves Myocardial Function Sebastiaan Hammer, Marieke Snel, Hildo J. Lamb, Ingrid M. Jazet, Rutger W. van der Meer, Hanno Pijl, Edo A. Meinders, Johannes A. Romijn, Albert de Roos, Johannes W. A. Smit In type 2 diabetes mellitus (T2DM), myocardial triglyceride (TG) stores are increased. We studied the effects of prolonged caloric restriction on myocardial TG content, myocardial function, and glucoregulation in obese patients with T2DM. Caloric restriction decreased body weight associated with improved glucoregulation, a decrease in myocardial TG content, and improvements in diastolic function. We conclude that myocardial TG stores in obese patients with T2DM are flexible and amendable to therapeutic intervention by caloric restriction. Therefore, the data emphasize the potential relevance of measuring myocardial TG content as a surrogate marker to assess the effects of metabolic interventions on the heart.