Microglia, complement and schizophrenia

Excessive synapse elimination during adolescence and early adulthood has long been hypothesized to underpin the emergence of schizophrenia. A new study reports that induced microglia-like cells derived from schizophrenia patients display increased synapse engulfment, which may be partly mediated by...

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Published in:	Nature neuroscience Vol. 22; no. 3; pp. 333 - 334
Main Authors:	Wang, Meiyan, Zhang, Lei, Gage, Fred H.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-03-2019 Nature Publishing Group
Subjects:	631/378/1689/1799 631/378/2596/1953 Adolescents Animal Genetics and Genomics Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Humans Mental disorders Microglia Neurobiology Neuronal Plasticity Neurosciences News & Views news-and-views Schizophrenia Synapse elimination Synapses
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Abstract	Excessive synapse elimination during adolescence and early adulthood has long been hypothesized to underpin the emergence of schizophrenia. A new study reports that induced microglia-like cells derived from schizophrenia patients display increased synapse engulfment, which may be partly mediated by a genetic schizophrenia-risk variant.
AbstractList	Excessive synapse elimination during adolescence and early adulthood has long been hypothesized to underpin the emergence of schizophrenia. A new study reports that induced microglia-like cells derived from schizophrenia patients display increased synapse engulfment, which may be partly mediated by a genetic schizophrenia-risk variant.
Audience	Academic
Author	Gage, Fred H. Zhang, Lei Wang, Meiyan
Author_xml	– sequence: 1 givenname: Meiyan surname: Wang fullname: Wang, Meiyan organization: Laboratory of Genetics, The Salk Institute for Biological Studies, Neurobiology Section, Division of Biological Sciences, University of California San Diego – sequence: 2 givenname: Lei surname: Zhang fullname: Zhang, Lei organization: Laboratory of Genetics, The Salk Institute for Biological Studies – sequence: 3 givenname: Fred H. orcidid: 0000-0002-0938-4106 surname: Gage fullname: Gage, Fred H. email: gage@salk.edu organization: Laboratory of Genetics, The Salk Institute for Biological Studies
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Snippet	Excessive synapse elimination during adolescence and early adulthood has long been hypothesized to underpin the emergence of schizophrenia. A new study reports...
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Title	Microglia, complement and schizophrenia
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