Microglia, complement and schizophrenia

Microglia, complement and schizophrenia

Excessive synapse elimination during adolescence and early adulthood has long been hypothesized to underpin the emergence of schizophrenia. A new study reports that induced microglia-like cells derived from schizophrenia patients display increased synapse engulfment, which may be partly mediated by...

Full description

Saved in:
Bibliographic Details
Published in:Nature neuroscience Vol. 22; no. 3; pp. 333 - 334
Main Authors: Wang, Meiyan, Zhang, Lei, Gage, Fred H.
Format: Journal Article
Language:English
Published: New York Nature Publishing Group US 01-03-2019
Nature Publishing Group
Subjects:
631/378/1689/1799
631/378/2596/1953
Adolescents
Animal Genetics and Genomics
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Humans
Mental disorders
Microglia
Neurobiology
Neuronal Plasticity
Neurosciences
News & Views
news-and-views
Schizophrenia
Synapse elimination
Synapses
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Excessive synapse elimination during adolescence and early adulthood has long been hypothesized to underpin the emergence of schizophrenia. A new study reports that induced microglia-like cells derived from schizophrenia patients display increased synapse engulfment, which may be partly mediated by a genetic schizophrenia-risk variant.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:1097-6256
1546-1726
DOI:10.1038/s41593-019-0343-1