Molecular Inactivation: Spatially and temporally defined molecular knockouts

Molecular Inactivation: Spatially and temporally defined molecular knockouts

Most monoclonal antibodies do not functionally inactivate the antigen they recognize. This limitation can be overcome by localized chromophore-assisted laser inactivation (CALI) of specific antibody-linked proteins.

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Bibliographic Details
Published in:Current biology Vol. 5; no. 11; pp. 1255 - 1256
Main Authors: Müller, Bernhard K., Bonhoeffer, Friedrich
Format: Journal Article
Language:English
Published: England Elsevier Inc 01-11-1995
Subjects:
Animals
Antibodies, Monoclonal - chemistry
Antibodies, Monoclonal - immunology
Antigens - chemistry
Antigens - immunology
Coloring Agents
Lasers
Protein Denaturation
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Description
Summary:Most monoclonal antibodies do not functionally inactivate the antigen they recognize. This limitation can be overcome by localized chromophore-assisted laser inactivation (CALI) of specific antibody-linked proteins.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(95)00251-X