Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women

• Published in: Breast cancer targets and therapy Vol. 3; no. default; pp. 27 - 33
• Main Authors: Patil, Amit V, Bhamre, Rahul S, Singhai, Rajeev, Tayade, Mukund B, Patil, Vinayak W
• Format: Journal Article
• Language: English
• Published: New Zealand Taylor & Francis Ltd 01-01-2011; Dove Press; Dove Medical Press
• Subjects: hormone receptors; immunohistochemistry; Original Research; prognostic cancer tissue biomarkers; steroid receptors; prognostic cancer tissue biomarkers; immunohistochemistry; steroid receptors; hormone receptors
• ISSN: 1179-1314; 1179-1314
• DOI: 10.2147/BCTT.S17892

To determine the expressions and relationship between estrogen receptors (ERs) and progesterone receptors (PgRs) in breast cancer in Indian women.
Surgically removed breast cancer tissues were collected from Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India, taking (n = 300) cases of infiltrating duct cancer of Indian women after radical mastectomy and lumpectomy; the age- and menopausal-related subgroups satisfied this requirement.
Statistical significance was calculated by the likelihood ratio test; relative risk served to check for significant differences. Relapse-free interval probabilities were calculated according to Kaplan and Meier, with Cox-Mantel test comparing survival functions and P values.
We observed that only in middle-aged postmenopausal patients bearing pT2 tumors were ER and PgR receptors shown to have a prognostic significance with the lowest tested cutoff value being 5 fmol/mg.
Immunohistochemistry analysis has been shown to be a prognostic factor for patients with breast cancer; the major aim of determining the ER receptor status is to assess predictive response to hormonal therapy.