Keloids and neoplasms in the Rubinstein-Taybi syndrome

In a series of 574 individuals with the Rubinstein-Taybi syndrome, 28 had keloids, and 19 had one or more neoplasms. The array of malignant neoplasms does not suggest an etiology or pathogenesis in common. One possible exception is that four cases of leukemia were observed. When the data for maligna...

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Bibliographic Details
Published in:	Medical and pediatric oncology Vol. 17; no. 6; p. 485
Main Authors:	Siraganian, P A, Rubinstein, J H, Miller, R W
Format:	Journal Article
Language:	English
Published:	United States 1989
Subjects:	Abnormalities, Multiple Adolescent Adult Child Child, Preschool Female Humans Infant Infant, Newborn Keloid - etiology Male Middle Aged Neoplasms - etiology Rubinstein-Taybi Syndrome - complications
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Summary:	In a series of 574 individuals with the Rubinstein-Taybi syndrome, 28 had keloids, and 19 had one or more neoplasms. The array of malignant neoplasms does not suggest an etiology or pathogenesis in common. One possible exception is that four cases of leukemia were observed. When the data for malignant and benign neoplasms were combined, at least nine of the 22 could have arisen from developmental errors. The apparent excess of keloid formation indicates overreaction to mild injury, with no known relevance to neoplasia but of potential interest in future studies of scar formation.
ISSN:	0098-1532
DOI:	10.1002/mpo.2950170526