Cholera Toxin and Heat-Labile Enterotoxin Activate Human Monocyte-Derived Dendritic Cells and Dominantly Inhibit Cytokine Production through a Cyclic AMP-Dependent Pathway

• Published in: Infection and Immunity Vol. 70; no. 10; pp. 5533 - 5539
• Main Authors: BAGLEY, Kenneth C, ABDELWAHAB, Sayed F, TUSKAN, Robert G, FOUTS, Timothy R, LEWIS, George K
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-10-2002
• Subjects: Adjuvants, Immunologic - chemistry; Adjuvants, Immunologic - pharmacology; Analysis of the immune response. Humoral and cellular immunity; Bacterial Toxins - chemistry; Bacterial Toxins - pharmacology; Biological and medical sciences; Bucladesine - pharmacology; CD4-Positive T-Lymphocytes - immunology; Cell Communication; Cell Differentiation - drug effects; Cellular Microbiology: Pathogen-Host Cell Molecular Interactions; Cholera Toxin - chemistry; Cholera Toxin - pharmacology; Colforsin - pharmacology; Cyclic AMP - metabolism; Cytokines - biosynthesis; Dendritic Cells - cytology; Dendritic Cells - drug effects; Dendritic Cells - immunology; Dendritic Cells - metabolism; Enterotoxins - chemistry; Enterotoxins - pharmacology; Escherichia coli Proteins; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunity, Mucosal; Immunobiology; In Vitro Techniques; Interleukin-12 - biosynthesis; Monocytes - cytology; Monocytes - drug effects; Monocytes - immunology; Monocytes - metabolism; Organs and cells involved in the immune response; Protein Structure, Tertiary; Tumor Necrosis Factor-alpha - biosynthesis; Human; Dendritic cell; Cytokine; Cyclic AMP; Infection; Toxin; Signal transduction; Immunogenicity; Immunological adjuvant; Production; Bacteriosis; Enterotoxin; Cholera
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.70.10.5533-5539.2002

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