Tumour necrosis factor, a key role in obesity?

Tumour necrosis factor, a key role in obesity?

Tumour necrosis factor-α (TNF) is a pleiotropic cytokine involved in many metabolic responses in both normal and pathophysiological states. In spite of the fact that this cytokine (also known as “cachectin”) has been related to many of the metabolic abnormalities associated with cachexia, recent stu...

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Bibliographic Details
Published in:FEBS Letters Vol. 451; no. 3; pp. 215 - 219
Main Authors: Bulló-Bonet, M., García-Lorda, P., López-Soriano, F.J., Argilés, J.M., Salas-Salvadó, J.
Format: Book Review Journal Article
Language:English
Published: England Elsevier B.V 28-05-1999
Subjects:
Adipose tissue
Adipose Tissue - metabolism
Energy Metabolism
Humans
Insulin resistance
Obesity
Obesity - metabolism
TNF
Tumor Necrosis Factor-alpha - metabolism
Obesity
Insulin resistance
Adipose tissue
TNF
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Summary:Tumour necrosis factor-α (TNF) is a pleiotropic cytokine involved in many metabolic responses in both normal and pathophysiological states. In spite of the fact that this cytokine (also known as “cachectin”) has been related to many of the metabolic abnormalities associated with cachexia, recent studies suggest that TNF may also have a central role in obesity modulating energy expenditure, fat deposition and insulin resistance. This review deals with the role of TNF in the control of fat mass and obesity.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)00540-2