Anthraquinone Derivatives from a Marine-Derived Fungus Sporendonema casei HDN16-802

• Published in: Marine drugs Vol. 17; no. 6; p. 334
• Main Authors: Ge, Xueping, Sun, Chunxiao, Feng, Yanyan, Wang, Lingzhi, Peng, Jixing, Che, Qian, Gu, Qianqun, Zhu, Tianjiao, Li, Dehai, Zhang, Guojian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04-06-2019; MDPI
• Subjects: Anthraquinone; anthraquinone derivatives; Anthraquinones; antibacterial activities; Antibiotics; Anticoagulants; Chlorine; Chlorine compounds; Chromatography; Circular dichroism; cytotoxic activities; Cytotoxicity; Derivatives; Dichroism; Fungi; Laboratories; marine-derived fungus; Metabolism; Metabolites; Minimum inhibitory concentration; NMR; Nuclear magnetic resonance; Spectroscopic techniques; Sporendonema casei; China; cytotoxic activities; Sporendonema casei; antibacterial activities; anthraquinone derivatives; marine-derived fungus
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md17060334

Five new anthraquinone derivatives, auxarthrols D-H (
-
), along with two known analogues (
-
), were obtained from the culture of the marine-derived fungus
. Their structures, including absolute configurations, were established on the basis of NMR, HRESIMS, and circular dichroism (CD) spectroscopic techniques. Among them, compound
represents the second isolated anthraquinone derivative with a chlorine atom, which, with compound
, are the first reported anthraquinone derivatives with anticoagulant activity. Compounds
and
showed cytotoxic activities with IC
values from 4.5 μM to 22.9 μM, while compounds
,
-
, and
-
showed promising antibacterial activities with MIC values from 12.5 μM to 200 μM. In addition, compound
was discovered to display potential antitubercular activity for the first time.