pH and Redox Dual-Responsive MSN-S-S-CS as a Drug Delivery System in Cancer Therapy

• Published in: Materials Vol. 13; no. 6; p. 1279
• Main Authors: Xu, Yanqin, Xiao, Liyue, Chang, Yating, Cao, Yuan, Chen, Changguo, Wang, Dan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12-03-2020; MDPI
• Subjects: Cancer; Cancer therapies; Chemical bonds; Chitosan; Controlled release; double response; drug delivery; Drug delivery systems; drug release; Drugs; Ethanol; Fluids; Fourier transforms; Glutathione; Loading rate; mesoporous silica nanoparticles; Nanoparticles; Particle size; Pore size; Porosity; Response functions; Salicylic acid; Silicon dioxide; Simulation; Therapy; Zeta potential; Australia; United States > US; mesoporous silica nanoparticles; drug delivery; drug release; double response
• ISSN: 1996-1944; 1996-1944
• DOI: 10.3390/ma13061279

In order to achieve a controlled release drug delivery system (DDS) for cancer therapy, a pH and redox dual-responsive mesoporous silica nanoparticles (MSN)-sulfur (S)-S- chitosan (CS) DDS was prepared via an amide reaction of dithiodipropionic acid with amino groups on the surface of MSN and amino groups on the surface of CS. Using salicylic acid (SA) as a model drug, SA@MSN-S-S-CS was prepared by an impregnation method. Subsequently, the stability, swelling properties and drug release properties of the DDS were studied by x-ray diffraction, scanning electron microscopy, Fourier transform infrared microspectroscopy, size and zeta potential as well as Brunauer-Emmett-Teller surface area. Pore size and volume of the composites decreased after drug loading but maintained a stable structure. The calculated drug loading rate and encapsulation efficiency were 8.17% and 55.64%, respectively. The in vitro drug release rate was 21.54% in response to glutathione, and the release rate showed a marked increase as the pH decreased. Overall, double response functions of MSN-S-S-CS had unique advantages in controlled drug delivery, and may be a new clinical application of DDS in cancer therapy.