Advances in Anti-Diabetic Cognitive Dysfunction Effect of Erigeron Breviscapus (Vaniot) Hand-Mazz

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 16; no. 1; p. 50
• Main Authors: Gu, Shanye, Zhou, Ziyi, Zhang, Shijie, Cai, Yefeng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29-12-2022; MDPI
• Subjects: Acids; active ingredients; Alzheimer's disease; Animal cognition; Apoptosis; Brain research; Chinese medicine; Cognitive ability; Dementia; Diabetes; diabetic cognitive dysfunction; Erigeron breviscapus (vant.) hand-mazz; Flavonoids; Ingredients; Insulin resistance; Kinases; Memory; Metabolites; Oxidative stress; pathogenesis; Peptides; pharmacological effects; Phosphorylation; Proteins; Review; pathogenesis; Erigeron breviscapus (vant.) hand-mazz; active ingredients; pharmacological effects; diabetic cognitive dysfunction
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph16010050

Diabetic cognitive dysfunction (DCD) is the decline in memory, learning, and executive function caused by diabetes. Although its pathogenesis is unclear, molecular biologists have proposed various hypotheses, including insulin resistance, amyloid β hypothesis, tau protein hyperphosphorylation hypothesis, oxidative stress and neuroinflammation. DCD patients have no particular treatment options and current pharmacological regimens are suboptimal. In recent years, Chinese medicine research has shown that herbs with multi-component, multi-pathway and multi-target synergistic activities can prevent and treat DCD. Yunnan is home to the medicinal herb Erigeron breviscapus (Vant.) Hand-Mazz. (EBHM). Studies have shown that EBHM and its active components have a wide range of pharmacological effects and applications in cognitive disorders. EBHM's anti-DCD properties have been seldom reviewed. Through a literature study, we were able to evaluate the likely pathophysiology of DCD, prescribe anti-DCD medication and better grasp EBHM's therapeutic potential. EBHM's pharmacological mechanism and active components for DCD treatment were also summarized.