Triterpene glycosides with stimulatory activity on melanogenesis from the aerial parts of Weigela subsessilis

• Published in: Archives of pharmacal research Vol. 38; no. 8; pp. 1541 - 1551
• Main Authors: Won, Yu-Mi, Seong, Zuh-Kyung, Kim, Jae-Lim, Kim, Hui-Seong, Song, Hyuk-Hwan, Kim, Doo-Young, Kim, Jung-Hee, Oh, Sei-Ryang, Cho, Hyun-Woo, Cho, Jung-Hee, Lee, Hyeong-Kyu
• Format: Journal Article
• Language: English
• Published: Seoul Pharmaceutical Society of Korea 01-08-2015; 대한약학회
• Subjects: aerial parts; Animals; Caprifoliaceae; Cell Survival - drug effects; Cell Survival - physiology; chemical structure; glycosides; Glycosides - isolation & purification; Glycosides - pharmacology; kaempferol; Medicine; Melanins - metabolism; melanogenesis; melanoma; Melanoma, Experimental; Mice; Pharmacology/Toxicology; Pharmacy; Plant Components, Aerial; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Research Article; spectroscopy; Triterpenes - isolation & purification; Triterpenes - pharmacology; triterpenoids; Weigela; 약학; Caprifoliaceae; Lonicerosides K–M; Melanogenesis stimulatory activity; Triterpene glycoside
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-014-0524-0

Three new triterpene glycosides (Lonicerosides K, L and M) and 11 known compounds were isolated from the aerial parts of Weigela subsessilis. Among the known isolated compounds, loniceroside A, sweroside, kaempferol-3-O-glucopyranoside 6″-(3-hydroxy-3-methylglutarate), kaempferol-3-O-acetylglucoside and grandifloroside were reported for the first time in a Weigela genus plant. Their chemical structures were identified using extensive spectroscopic analysis including two-dimensional (2D)-NMR experiments, HR-ESI-QTOF-MS and comparison with reported data. Among these compounds, lonicerosides A and L had potent melanogenesis stimulatory activity in murine B16F0 melanoma cells. The structural relationship of active compounds was discussed.