Diet and biomarkers of oxidative damage in women previously treated for breast cancer

• Published in: Nutrition and cancer Vol. 51; no. 2; pp. 146 - 154
• Main Authors: Thomson, C.A, Giuliano, A.R, Shaw, J.W, Rock, C.L, Ritenbaugh, C.K, Hakim, I.A, Hollenbach, K.A, Alberts, D.S, Pierce, J.P
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Lawrence Erlbaum Associates, Inc 01-01-2005; Taylor& Francis
• Subjects: anticarcinogenic activity; antioxidants; Antioxidants - administration & dosage; arachidonic acid; Biological and medical sciences; Biomarkers - urine; Body Mass Index; breast neoplasms; Breast Neoplasms - prevention & control; Breast Neoplasms - urine; Case-Control Studies; chemoprevention; Cohort Studies; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; Diet; dietary fat; Dietary Fats - administration & dosage; Dietary Fats - urine; Dinoprost - analogs & derivatives; Dinoprost - urine; disease prevention; DNA damage; DNA Damage - physiology; Fatty Acids, Unsaturated - administration & dosage; Fatty Acids, Unsaturated - urine; Female; food intake; fruits (food); Gynecology. Andrology. Obstetrics; Humans; Lipid Peroxidation - physiology; low fat diet; Mammary gland diseases; Medical sciences; Middle Aged; nutritional intervention; oxidative stress; Oxidative Stress - physiology; polyunsaturated fatty acids; saturated fatty acids; Secondary Prevention; Time Factors; Tumors; vegetables; vitamin E; women; Biological marker; Arachidonic acid; Eicosanoid; Female; Damage; Woman; Human; Urine; Feeding behavior; ISO; Arachidonic acid derivatives; Polyunsaturated fatty acid; Breast cancer; Saturated fat; Malignant tumor; Antioxidant; Feeding; Prostaglandin F2α; Mammary gland diseases; Deoxyguanosine; Treatment; Diet; Saturated fatty acid; Food intake; Fat; Level
• ISSN: 0163-5581; 1532-7914
• DOI: 10.1207/s15327914nc5102_4

This study sought to evaluate the relationship between dietary intake of fat, polyunsaturated fat, saturated fat, arachidonic acid, and selected dietary antioxidants and levels of oxidative damage as measured by urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-epi-prostaglandin F2alpha (8-iso-PGF2alpha) in women previously treated for breast cancer. Two hundred two study subjects participating in the Women's Healthy Eating and Living (WHEL) study were included in this ancillary study. Dietary intakes and concentrations of urinary 8-OHdG and 8-iso-PGF2alpha were measured at baseline and 12 mo in the 179 women included in the analytical cohort. Study subjects demonstrated a significant reduction in dietary total, polyunsaturated, and saturated fat intake and a significant increase in vitamins E and C and beta-carotene intake from baseline to 12 mo. Linear mixed-models analysis using baseline and Year 1 data indicated that vitamin E intake was inversely associated with both 8-OHdG and 8-iso-PGF2alpha. 8-Iso-PGF2alpha is increased with increased body mass index (BMI) and polyunsaturated fatty acid (PUFA) intake, indicating an increase in lipid peroxidation with greater BMI and higher PUFA intake. 8-OHdG was inversely related to age but positively related to arachidonic acid, indicating an increase in DNA damage with higher intake of arachidonic acid (meat). The results of this nested case-controlled study provide potential mechanisms by which a high fruit and vegetable, low-fat diet might reduce the recurrence rate of or early-stage breast cancer.