Voltammetric Evaluation of Diclofenac Tablets Samples through Carbon Black-Based Electrodes

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 12; no. 2; p. 83
• Main Authors: da Cunha, Carlos Eduardo Peixoto, Rodrigues, Edson Silvio Batista, Fernandes Alecrim, Morgana, Thomaz, Douglas Vieira, Macêdo, Isaac Yves Lopes, Garcia, Luane Ferreira, de Oliveira Neto, Jerônimo Raimundo, Moreno, Emily Kussmaul Gonçalves, Ballaminut, Nara, de Souza Gil, Eric
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04-06-2019; MDPI
• Subjects: anti-inflammatory drugs; Biosensors; Carbon black; Electrodes; Graphite; Nanostructured materials; Nonsteroidal anti-inflammatory drugs; pencil graphite electrodes; pharmaceutical electroanalysis; Pharmaceuticals; stability assays; Voltammetry; anti-inflammatory drugs; pencil graphite electrodes; stability assays; pharmaceutical electroanalysis
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph12020083

Diclofenac (DIC) is a non-steroidal anti-inflammatory drug of wide use around the world. Electroanalytical methods display a high analytical potential for application in pharmaceutical samples but the drawbacks concerning electrode fouling and reproducibility are of major concern. Henceforth, the aim of this work was to propose the use of alternative low-cost carbon black (CB) and ionic liquid (IL) matrix to modify the surface of pencil graphite electrodes (PGE) in order to quantify DIC in raw materials, intermediates, and final products, as well as in stability assays of tablets. The proposed method using CB+IL/PGE displayed good recovery (99.4%) as well as limits of detection (LOD) of 0.08 µmol L-1 and limits of quantification (LOQ) of 0.28 µmol L
. CB+IL/PGE response was five times greater than the unmodified PGE. CB+IL-PGE stands as an interesting alternative for DIC assessment in different pharmaceutical samples.