Randomized Controlled Clinical Trial of Nanostructured Carbonated Hydroxyapatite for Alveolar Bone Repair

• Published in: Materials Vol. 12; no. 22; p. 3645
• Main Authors: Resende, Rodrigo F B, Sartoretto, Suelen C, Uzeda, Marcelo J, Alves, Adriana T N N, Calasans-Maia, José A, Rossi, Alexandre M, Granjeiro, José Mauro, Calasans-Maia, Mônica D
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06-11-2019; MDPI
• Subjects: Adsorption; Biocompatibility; Biodegradation; Biomedical materials; bone loss; calcium phosphate; Carbonation; clinical trial; Dentistry; Hydroxyapatite; Morphology; Nanostructure; Particle size; Phosphorus; Statistical analysis; Statistical methods; Substitute bone; xenograft; Xenotransplantation; Brazil; Rio de Janeiro Brazil; United States > US; Japan; clinical trial; xenograft; calcium phosphate; bone loss
• ISSN: 1996-1944; 1996-1944
• DOI: 10.3390/ma12223645

The properties of the biodegradation of bone substitutes in the dental socket after extraction is one of the goals of regenerative medicine. This double-blind, randomized, controlled clinical trial aimed to compare the effects of a new bioabsorbable nanostructured carbonated hydroxyapatite (CHA) with a commercially available bovine xenograft (Bio-Oss
) and clot (control group) in alveolar preservation. Thirty participants who required tooth extraction and implant placement were enrolled in this study. After 90 days, a sample of the grafted area was obtained for histological and histomorphometric evaluation and an implant was installed at the site. All surgical procedures were successfully carried out without complications and none of the patients were excluded. The samples revealed a statistically significant increase of new bone formation (NFB) in the CHA group compared with Bio-Oss
after 90 days from surgery (
< 0.05). However, the clot group presented no differences of NFB compared to CHA and Bio-Oss
. The CHA group presented less amount of reminiscent biomaterial compared to Bio-Oss
. Both biomaterials were considered osteoconductors, easy to handle, biocompatible, and suitable for alveolar filling. Nanostructured carbonated hydroxyapatite spheres promoted a higher biodegradation rate and is a promising biomaterial for alveolar socket preservation before implant treatment.