Metabolic adaptation in IUGR neonates determined with microdialysis — a pilot study

• Published in: Early human development Vol. 42; no. 1; pp. 1 - 14
• Main Authors: Horal, Mikael, Ungerstedt, Urban, Persson, Bengt, Westgren, Magnus, Marcus, Claude
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier Ireland Ltd 12-05-1995; New York,NY Elsevier; Amsterdam
• Subjects: Adipose Tissue - chemistry; Biological and medical sciences; Blood Glucose - analysis; Diseases of mother, fetus and pregnancy; Female; Fetal Growth Retardation - blood; Fetal Growth Retardation - metabolism; Glucose; Glycerol; Glycerol - analysis; Glycerol - blood; Gynecology. Andrology. Obstetrics; Humans; Infant, Newborn - blood; Infant, Newborn - metabolism; Infant, Small for Gestational Age - blood; Infant, Small for Gestational Age - metabolism; Lactate; Lactates - analysis; Lactates - blood; Male; Medical sciences; Medicin och hälsovetenskap; Microdialysis; Microdialysis - methods; Neonates; Pilot Projects; Pregnancy. Fetus. Placenta; Small-for-gestational-age; Neonates; Microdialysis; CPAP; Lactate; IUGR; SGA-T/PT; AGA-T; Small-for-gestational-age; Glycerol; Glucose; Human; Pregnancy disorders; Lactates; Fetal diseases; Fetal hypotrophy; Newborn; Subcutaneous administration; Diagnosis; Measurement method; Technique; Glycemia
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/0378-3782(95)01628-G

Subcutaneous microdialysis was used to monitor the immediate metabolic changes with respect to glucose, glycerol and lactate in the extracellular space of adipose tissue among five small-for-gestational-age (SGA) and two appropriate-for-gestational-age (AGA) newborns. There was a good correlation between glucose levels in blood and dialysate (
r = 0.97,
n = 14). The infants showed rapid rises and falls in dialysate glucose levels that are not seen among older children and adults. The levels of lactate were higher than those reported in blood. Lactate may serve as an alternative source of energy for the neonate. Microdialysis is of potential value in increasing our understanding of metabolic events. It provides a safe on-line means of making continuous measurements in these fragile patients in order to detect periods of hypoglycaemia, at least in infants with a birth weight >1000 g.