Anaphylaxis to intravenous gentamicin with suspected sensitization through gentamicin-loaded bone cement

• Published in: The journal of allergy and clinical immunology in practice (Cambridge, MA) Vol. 4; no. 6; pp. 1258 - 1259.e1
• Main Authors: Christiansen, Ida Skovgaard, MD, Pedersen, Poul, MD, Krøigaard, Mogens, MD, Mosbech, Holger, MD, DMSc, Garvey, Lene Heise, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-11-2016; Elsevier Limited
• Subjects: Aged; Allergies; Allergy and Immunology; Anaphylaxis - chemically induced; Anaphylaxis - immunology; Anesthesia; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Antibiotics; Arthroplasty, Replacement, Knee; Bone Cements - chemistry; Bone surgery; Cement; Drug dosages; Female; Gentamicins - administration & dosage; Gentamicins - adverse effects; Humans; Injections, Intravenous; Internal Medicine; Joint surgery; Patients; Prostheses
• ISSN: 2213-2198; 2213-2201
• DOI: 10.1016/j.jaip.2016.07.003

The histamine release test for gentamicin later proved positive and all other substances tested negative in all other tests. [...]she was diagnosed with immediate type allergy to gentamicin. Two weeks after surgery, she had been admitted to hospital on suspicion of deep venous thrombosis, which was not found on ultrasound, and infection was also ruled out. Because of unsatisfactory range of movement of the knee, 2 months after surgery, she underwent a manipulation of the joint under general anesthesia.