Effects of Coffee Intake on Dyslipidemia Risk According to Genetic Variants in the ADORA Gene Family among Korean Adults

• Published in: Nutrients Vol. 12; no. 2; p. 493
• Main Authors: Han, Jihee, Shon, Jinyoung, Hwang, Ji-Yun, Park, Yoon Jung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14-02-2020; MDPI
• Subjects: Adenosine; Adenosine receptors; Adult; Aged; Alleles; Asian Continental Ancestry Group - genetics; Blood pressure; Caffeine; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Coffee; Coffee - adverse effects; Cohort Studies; Dietary intake; Dyslipidemia; Dyslipidemias - etiology; Dyslipidemias - genetics; Dyslipidemias - prevention & control; Eating - genetics; Education; Energy consumption; Female; Genetic diversity; Genetic variability; Genetic variance; genetic variants; Genetic Variation - genetics; Genomes; Health risk assessment; Humans; Hypertension; korean genome and epidemiology study (koges); Lipids; Loci; Male; Metabolic disorders; Middle Aged; Multigene Family - genetics; Physiology; Population studies; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1 - genetics; Regression analysis; Risk; Sex Characteristics; genetic variants; Adenosine receptors; dyslipidemia; Korean Genome and Epidemiology Study (KoGES); coffee
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12020493

Current evidence on the effects of coffee intake on cardiovascular diseases is not consistent, in part contributed by the genetic variability of the study subjects. While adenosine receptors (ADORAs) are involved in caffeine signaling, it remains unknown how genetic variations at the
loci correlate the coffee intake with cardiovascular diseases. The present study examined the associations of coffee intake with dyslipidemia risk depending on genetic variants in the
gene family. The study involved a population-based cohort of 4898 Korean subjects. Consumption of more than or equal to a cup of coffee per day was associated with lower dyslipidemia risk in females carrying the
minor allele rs2779212 (OR: 0.645, 95% CI: 0.506-0.823), but not in those with the major allele. At the
locus, male subjects with the minor allele of rs5760423 showed instead an increased risk of dyslipidemia when consuming more than or equal to a cup of coffee per day (OR: 1.352, 95% CI: 1.014-1.802). The effect of coffee intake on dyslipidemia risk differs depending on genetic variants at the
loci in a sex-specific manner. Our study suggests that a dietary guideline for coffee intake in the prevention and management of dyslipidemia ought to consider ADORA-related biomarkers carefully.