The effect of topically applied progesterone on sebum excretion rate

There is evidence that anti-androgens may help in the treatment of acne vulgaris. We therefore performed a double-blind trial to assess the effect of topically applied progesterone on sebum excretion rate. Thirty-eight patients took part in the trial which was for 3 months. The preparation had no ef...

Full description

Saved in:

Bibliographic Details
Published in:	British journal of dermatology (1951) Vol. 100; no. 6; p. 687
Main Authors:	Simpson, N B, Bowden, P E, Forster, R A, Cunliffe, W J
Format:	Journal Article
Language:	English
Published:	England 01-06-1979
Subjects:	Acne Vulgaris - physiopathology Administration, Topical Adolescent Adult Clinical Trials as Topic Depression, Chemical Double-Blind Method Female Humans Male Middle Aged Progesterone - administration & dosage Progesterone - pharmacology Sebum - metabolism Secretory Rate - drug effects Sex Factors Skin - metabolism
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	There is evidence that anti-androgens may help in the treatment of acne vulgaris. We therefore performed a double-blind trial to assess the effect of topically applied progesterone on sebum excretion rate. Thirty-eight patients took part in the trial which was for 3 months. The preparation had no effect in males. However, a significant reduction in sebum excretion rate was found in females, the effect being maximal at the end of the second month. There was a significant loss of effect at the end of the third month and this was not related to deterioration of the progesterone preparation.
ISSN:	0007-0963
DOI:	10.1111/j.1365-2133.1979.tb08073.x