Parathyroid hormone/parathyroid hormone-related peptide receptor 1 expression in odontogenic cystic lesions

• Published in: International endodontic journal Vol. 45; no. 3; pp. 209 - 214
• Main Authors: Lima, A. C., Fregnani, E. R., Silva-Sousa, Y. T. C., da Cruz Perez, D. E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-03-2012
• Subjects: Chromogenic Compounds; Dentigerous Cyst - pathology; dentigerous cysts; Dentistry; Endothelial Cells - pathology; Epithelial Cells - pathology; Epithelium - pathology; Fibroblasts - pathology; Humans; Immunohistochemistry; keratocystic odontogenic tumour; Mesoderm - pathology; odontogenic cysts; Odontogenic Cysts - pathology; Odontogenic Tumors - pathology; Parathyroid Hormone - analysis; PTHR1; radicular cyst; Radicular Cyst - pathology; Receptor, Parathyroid Hormone, Type 1 - analysis
• ISSN: 0143-2885; 1365-2591
• DOI: 10.1111/j.1365-2591.2011.01961.x

Lima AC, Fregnani ER, Silva‐Sousa YTC, da Cruz Perez DE. Parathyroid hormone/parathyroid hormone‐related peptide receptor 1 (PTHR1) expression in odontogenic cystic lesions. International Endodontic Journal, 45, 209–214, 2012.
Aim  To evaluate parathyroid hormone/parathyroid hormone‐related peptide receptor 1 (PTHR1) expression in odontogenic cystic lesions and to compare immunoexpression between the lesions.
Methodology  Thirty‐five radicular cysts, 22 dentigerous cysts and 17 keratocystic odontogenic tumours were evaluated. Immunohistochemical reactions against PHTR1 were carried out in 3‐μm histological sections, and the expression and the intensity of PTHR1 expression were evaluated. For statistical analysis, the Fisher exact test was used, with a significance of 5%.
Results  The intensity of expression in the epithelial lining was significantly weaker in the radicular cyst (P = 0.007). However, in the fibrous capsule, the radicular cyst presented higher positivity for PTHR1 (P = 0.04).
Conclusions  The probable co‐expression of PTHrP and PTHR1 in odontogenic cystic lesions may eventually have an autocrine and/or paracrine stimulus in the epithelial and mesenchymal cells, inducing proliferation and lesion growth.