Protective Effect of Naringenin Against Lead-Induced Oxidative Stress in Rats

• Published in: Biological trace element research Vol. 146; no. 3; pp. 354 - 359
• Main Authors: Wang, Jicang, Yang, Zijun, Lin, Lin, Zhao, Zhanqin, Liu, Zongping, Liu, Xuezhong
• Format: Journal Article
• Language: English
• Published: New York Humana Press Inc 01-06-2012; Springer Nature B.V
• Subjects: Alanine transaminase; Animals; Antioxidants; Antioxidants - administration & dosage; Antioxidants - pharmacology; Biochemistry; Biomarkers - analysis; Biomedical and Life Sciences; Biotechnology; Flavanones - administration & dosage; Flavanones - pharmacology; Hepatotoxicity; Kidney - chemistry; Kidney - enzymology; Kidney - metabolism; Kidneys; Lead poisoning; Life Sciences; Liver; Liver - chemistry; Liver - enzymology; Liver - metabolism; Male; Nutrition; Oncology; Organometallic Compounds - administration & dosage; Organometallic Compounds - antagonists & inhibitors; Organometallic Compounds - toxicity; Oxidative stress; Oxidative Stress - drug effects; Rats; Rats, Sprague-Dawley; Rodents; Trace elements; Urea; Antioxidants; Lead; Oxidative stress; Naringenin; Liver; Kidney
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-011-9268-6

Oxidative stress is thought to be involved in lead-induced toxicity. The aim of this study was to investigate the possible protective role of naringenin on lead-induced oxidative stress in the liver and kidney of rats. In the present investigation, lead acetate (500 mg Pb/L) was administered orally for 8 weeks to induce hepatotoxicity and nephrotoxicity. The levels of hepatic and renal markers such as alanine aminotransferase, aspartate aminotransferase, urea, uric acid, and creatinine were significantly (
P
 < 0.05) increased following lead acetate administration. Lead-induced oxidative stress in liver and kidney tissue was indicated by a significant (
P
 < 0.05) increase in the level of maleic dialdehyde and decreased levels of reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase. Naringenin markedly attenuated lead-induced biochemical alterations in serum, liver, and kidney tissues (
P
 < 0.05). The present study suggests that naringenin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in the liver and kidney of rats.