Identification of rTid-1, the rat homologue of the drosophila tumor suppressor l(2)tid gene

• Published in: Molecular and cellular biochemistry Vol. 258; no. 1-2; pp. 183 - 189
• Main Authors: Fujita, Masako, Nagai, Yasuo, Sawada, Tohru, Heese, Klaus
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01-03-2004
• Subjects: Alzheimer's disease; Animals; Apoptosis; Apoptosis - genetics; Apoptosis - physiology; Autoimmune diseases; Cell Line; Drosophila; Drosophila Proteins - genetics; Genes, Tumor Suppressor; GRP75 protein; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; HSP70 Heat-Shock Proteins - metabolism; Insects; Mortality; Neurons - metabolism; Protein Binding - genetics; Protein Isoforms - genetics; Protein Isoforms - metabolism; Rats; Rodents; Sequence Homology; Tid-1 gene
• ISSN: 0300-8177; 1573-4919
• DOI: 10.1023/b:mcbi.0000012854.84126.69

Active cell death ('apoptosis' or 'programmed cell death') is essential in the development and homeostasis of multicellular organisms and abnormal inhibition of apoptosis is an indicator of cancer and autoimmune diseases, whereas excessive cell death is implicated in neurodegenerative disorders such as Alzheimer's disease (AD). Here we demonstrate new isoforms of the rat homologue of the drosophila tumor suppressor l(2)tid gene (rTid-1). Moreover, we show that rTid-1 interacts isoform-specifically with the heat-shock-cognate-glucose-regulated protein hscGRP75 and neither induces nor inhibits directly neuronal apoptosis. This finding points to a pivotal role of Tid-1 in the control of cellular survival.