A Novel Model of Perifascial Areolar Tissue Transplant in Rats

• Published in: Indian journal of plastic surgery Vol. 55; no. 3; pp. 268 - 271
• Main Authors: Oshima, Junya, Sasaki, Kaoru, Shibuya, Yoichiro, Sekido, Mitsuru
• Format: Journal Article
• Language: English
• Published: A-12, 2nd Floor, Sector 2, Noida-201301 UP, India Thieme Medical and Scientific Publishers Pvt. Ltd 01-06-2022; Thieme Medical Publishers, Inc
• Subjects: bone exposure; grafts; loose connective tissue; Original; Original Article; perifascial areolar tissue; loose connective tissue; grafts; model; perifascial areolar tissue; bone exposure
• ISSN: 0970-0358; 1998-376X
• DOI: 10.1055/s-0042-1756130

Abstract
Background
 Perifascial areolar tissue (PAT) transplant is a method of transplanting loose connective tissue harvested in a sheet form from above the fascia to the wound bed and is effective for wounds with exposed ischemic tissue. However, the engraftment mechanism is unknown, and no animal models of PAT transplant for wound healing exist.
Methods
 In this study, we harvested connective tissue from the backs of Wistar rats in a sheet form to simulate a human PAT transplant. The PAT was affixed to exposed bone of the head.
Results
 In the PAT(+) group, the wound areas gradually decreased due to epithelialization and contraction. The wound area of the PAT(+) group was significantly smaller than that of the PAT(−) group.
Conclusions
 This clinically relevant rat model is useful for elucidating the mechanism of the PAT transplant and establishing a reliable surgical method.