Fatal Central Nervous System Disease Following First Infliximab Infusion in a Child With Inflammatory Bowel Disease

• Published in: Pediatric neurology Vol. 57; pp. 91 - 94
• Main Authors: Baumer, Fiona M., MD, Ouahed, Jodie, MD, MMSc, Verhave, Menno, MD, Rivkin, Michael J., MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-04-2016
• Subjects: acute hemorrhagic leukoencephalitis; AHLE; Central Nervous System Diseases - chemically induced; Central Nervous System Diseases - diagnostic imaging; Central Nervous System Diseases - mortality; Child; demyelinating disease; Fatal Outcome; Humans; inflammatory bowel disease; Inflammatory Bowel Diseases - drug therapy; infliximab; Infliximab - adverse effects; ischemic stroke; Magnetic Resonance Imaging; Male; Neurology; Pediatrics; primary sclerosing cholangitis; ulcerative colitis; acute hemorrhagic leukoencephalitis; demyelinating disease; infliximab; ulcerative colitis; primary sclerosing cholangitis; inflammatory bowel disease; ischemic stroke; AHLE
• ISSN: 0887-8994; 1873-5150
• DOI: 10.1016/j.pediatrneurol.2015.12.017

Abstract Background Infliximab is used in the treatment of inflammatory bowel disease. Previously reported neurological complications include central and peripheral demyelinating disorders and neuropathies occurring months into therapy. Patient Description A seven-year-old boy diagnosed with ulcerative colitis and primary sclerosing cholangitis received infliximab. Six hours following his uneventful infusion, he awoke with headache and emesis and rapidly became obtunded. Neurological examination revealed minimally reactive pupils and otherwise absent brainstem reflexes. Cranial computed tomography revealed hypodense lesions in the cerebral hemispheres, cerebellum, and pons accompanied by hemorrhage. Magnetic resonance imaging showed diffusion restriction concerning for ischemia with areas of ring enhancement suggestive of inflammation. Vessel imaging was normal, and cerebrospinal fluid and serum studies showed only an extremely elevated level of d-dimer. Echocardiogram showed depressed ventricular function but neither intracardiac shunt nor thrombus. Within four days he met criteria for brain death. Autopsy was refused. Conclusions This is the first report of a fulminant, fatal central nervous system process to occur after an initial dose of infliximab. The differential diagnosis includes multifocal arterial strokes and a devastating demyelinating process.