Sodium Nitroprusside for Advanced Low-Output Heart Failure

• Published in: Journal of the American College of Cardiology Vol. 52; no. 3; pp. 200 - 207
• Main Authors: Mullens, Wilfried, MD, Abrahams, Zuheir, MD, PhD, Francis, Gary S., MD, FACC, Skouri, Hadi N., MD, Starling, Randall C., MD, MPH, FACC, Young, James B., MD, FACC, Taylor, David O., MD, FACC, Tang, W.H. Wilson, MD, FACC
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15-07-2008; Elsevier Limited
• Subjects: Biomarkers - blood; Blood pressure; cardiac output; Cardiology; Cardiotonic Agents - therapeutic use; Cardiovascular; Case-Control Studies; Drug Administration Schedule; Drug therapy; Female; heart failure; Heart Failure - blood; Heart Failure - drug therapy; Heart Failure - physiopathology; hemodynamics; Hemodynamics - drug effects; Hospitalization; Humans; inotropic agents; Internal Medicine; Male; Middle Aged; Mortality; Nitroprusside - administration & dosage; Nitroprusside - adverse effects; Nitroprusside - therapeutic use; Retrospective Studies; Risk Factors; Stroke Volume - drug effects; vasodilation; Vasodilator Agents - administration & dosage; Vasodilator Agents - adverse effects; Vasodilator Agents - therapeutic use; mPAP; heart failure; vasodilation; mean pulmonary arterial pressure; acute decompensated heart failure; PCWP; LV; mean systemic arterial pressure; pulmonary capillary wedge pressure; hemodynamics; cardiac output; inotropic agents; SNP; sodium nitroprusside; left ventricle/ventricular; MAP; ADHF
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2008.02.083

Sodium Nitroprusside for Advanced Low-Output Heart Failure Wilfried Mullens, Zuheir Abrahams, Gary S. Francis, Hadi N. Skouri, Randall C. Starling, James B. Young, David O. Taylor, W. H. Wilson Tang Inotropic drugs are often preferred over vasodilators in patients with end-stage, low-output heart failure. We reviewed consecutive patients admitted between 2000 and 2005 with acute decompensated heart failure with a cardiac index ≤2 l/min/m2 . Compared with control patients, treatment with sodium nitroprusside was associated with greater improvement in hemodynamics, higher rates of transitioning oral vasodilators at discharge, and lower rates of all-cause mortality and all-cause mortality/cardiac transplant without increase in rehospitalization, inotropic use, or worsening renal function.