A Monoclonal Fab Derived from a Human Nonimmune Phage Library Reveals a New Epitope on gp41 and Neutralizes Diverse Human Immunodeficiency Virus Type 1 Strains

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Published in:	Journal of Virology Vol. 81; no. 23; pp. 12946 - 12953
Main Authors:	GUSTCHINA, Elena, LOUIS, John M, LAM, Son N, BEWLEY, Carole A, CLORE, G. Marius
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-12-2007 American Society for Microbiology (ASM)
Subjects:	Amino Acid Substitution - genetics Antibodies, Monoclonal - immunology Antibodies, Viral - immunology Biological and medical sciences Cell Line Epitope Mapping Epitopes - immunology Fundamental and applied biological sciences. Psychology Gene Library HIV Envelope Protein gp41 - immunology HIV-1 - immunology Human immunodeficiency virus 1 Humans Immunoglobulin Fab Fragments - genetics Immunoglobulin Fab Fragments - immunology Microbiology Miscellaneous Mutagenesis, Site-Directed Neutralization Tests Vaccines and Antiviral Agents Virology Human Immunopathology Antigenic determinant HIV-1 virus Retroviridae AIDS Fab-Fragment Immune deficiency Lentivirus Strain Virology Infection Virus Viral disease Human immunodeficiency virus Phage
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Summary:	Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology. For an alternate route to JVI .asm.org, visit: JVI
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Corresponding author. Mailing address for G. Marius Clore: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0820. Phone: (301) 496 0782. Fax: (301) 496 0825. E-mail: mariusc@mail.nih.gov. Mailing address for Carole A. Bewley: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0820. Phone: (301) 594 5187. Fax: (301) 402 0008. E-mail: caroleb@mail.nih.gov
ISSN:	0022-538X 1098-5514
DOI:	10.1128/JVI.01260-07