Polymorphism of VEGF gene in susceptibility to chronic immune-mediated inflammatory diseases: a meta-analysis

• Published in: Rheumatology international Vol. 35; no. 8; pp. 1351 - 1360
• Main Authors: Wei, Ni, Chen, Zijia, Xue, Zhifeng, Zhu, Yuelan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-08-2015; Springer Nature B.V
• Subjects: Alleles; Arthritis, Rheumatoid - genetics; Asian Continental Ancestry Group - genetics; Autoimmune Diseases - genetics; Behcet Syndrome - genetics; Diabetes Mellitus, Type 1 - genetics; European Continental Ancestry Group - genetics; Genetic Predisposition to Disease; Giant Cell Arteritis - genetics; Graves Disease - genetics; Humans; Lupus Erythematosus, Systemic - genetics; Medicine; Medicine & Public Health; Mucocutaneous Lymph Node Syndrome - genetics; Odds Ratio; Original Article - Genes and Disease; Polymorphism, Single Nucleotide; Psoriasis - genetics; Rheumatology; Scleroderma, Systemic - genetics; Vascular Endothelial Growth Factor A - genetics; 405G>C; Immune-mediated inflammatory diseases; Vascular endothelial growth factor; Meta-analysis
• ISSN: 0172-8172; 1437-160X
• DOI: 10.1007/s00296-015-3279-0

Background
Vascular endothelial growth factor (VEGF) is an important angiogenic factor and may be connected with chronic immune-mediated inflammatory diseases (IMIDs) to some extent. However, previous researches about the relationship between the +405G>C (dbSNP: rs2010963) polymorphism in
VEGF
gene and the risk of IMIDs are controversial and inconsistent. So we conducted this meta-analysis to assess whether the relationship between the +405G>C polymorphism in the 5′-UTR region of
VEGF
gene and IMID susceptibility exists.
Methods
Our literature search was conducted on the PubMed, Embase, Web of science, Chinese National Knowledge Infrastructure, and Chinese Biomedical databases to retrieve for eligible studies. Odds ratios as well as their 95 % confidence intervals were utilized to deduce the possible relationship.
Results
A total number of 5175 patients with IMIDs and 7069 healthy controls from 27 case–control studies were included. For the overall eligible data collected in our meta-analysis, there was no marked relationship between +405G>C polymorphism and the risk of IMIDs. However, subgroup analysis by ethnicity suggested that +405C allele could be a protective factor for IMIDs in Asians, whereas an opposite conclusion was drawn in Caucasians.
Conclusion
Thus, we may come to the conclusion that the
VEGF
+405G>C polymorphism could be associated with IMIDs, and the correlation might vary with ethnic groups.