Impact of Statin Therapy on Plasma Uric Acid Concentrations: A Systematic Review and Meta-Analysis

Purpose The aim of this study was to ascertain the effect size of statins in modulating plasma uric acid concentrations. Data Sources A search was undertaken of the MEDLINE, SCOPUS, Web of Science and Google Scholar electronic databases. Study Selection Studies meeting the following criteria were in...

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Published in:	Drugs (New York, N.Y.) Vol. 76; no. 9; pp. 947 - 956
Main Authors:	Derosa, Giuseppe, Maffioli, Pamela, Reiner, Željko, Simental-Mendía, Luis E., Sahebkar, Amirhossein
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-06-2016 Springer Nature B.V
Subjects:	Atorvastatin Calcium - therapeutic use Bias Cholesterol Clinical trials Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hyperuricemia - drug therapy Internal Medicine Medicine Medicine & Public Health Meta-analysis Metabolic disorders Pharmacology/Toxicology Pharmacotherapy Plasma Randomized Controlled Trials as Topic Rheumatism Simvastatin - therapeutic use Statins Systematic Review Uric acid Uric Acid - blood Uric Acid Atorvastatin Pravastatin Simvastatin Statin Therapy
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Summary:	Purpose The aim of this study was to ascertain the effect size of statins in modulating plasma uric acid concentrations. Data Sources A search was undertaken of the MEDLINE, SCOPUS, Web of Science and Google Scholar electronic databases. Study Selection Studies meeting the following criteria were included: (i) randomized controlled trials with either a parallel or crossover design; (ii) investigated the impact of statin therapy on plasma uric acid concentrations; and (iii) presentation of sufficient information on uric acid values at baseline and at the end of follow-up in each group, or presenting the net change. Data Synthesis The present meta-analysis suggested a significant reduction in plasma uric acid levels following statin therapy; however, this does not seem to be a class effect as subgroup analysis revealed a significant reduction with atorvastatin and simvastatin only, and not with pravastatin and rosuvastatin. Conclusions Atorvastatin and simvastatin, but not the other statins, can reduce serum uric acid levels.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-4 content type line 23 ObjectType-Undefined-3 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0012-6667 1179-1950
DOI:	10.1007/s40265-016-0591-2