Phase equilibria and thermodynamics of p-hydroxybenzoic acid

Phase equilibria and thermodynamics of p-hydroxybenzoic acid

The prevalence of phases and associated solubilities of p-hydroxybenzoic acid have been investigated in methanol, acetonitrile, acetic acid, acetone, water, and ethyl acetate at temperatures from 10 to 50 degrees C. Thermodynamic data was acquired through determination of van't Hoff enthalpy of...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences Vol. 95; no. 4; p. 748
Main Authors: Nordström, Fredrik L, Rasmuson, Ake C
Format: Journal Article
Language:English
Published: United States 01-04-2006
Subjects:
Acetates - chemistry
Acetic Acid - chemistry
Acetone - chemistry
Acetonitriles - chemistry
Crystallization
Methanol - chemistry
Parabens - chemistry
Phase Transition
Solubility
Solvents - chemistry
Thermodynamics
Transition Temperature
Water - chemistry
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Summary:The prevalence of phases and associated solubilities of p-hydroxybenzoic acid have been investigated in methanol, acetonitrile, acetic acid, acetone, water, and ethyl acetate at temperatures from 10 to 50 degrees C. Thermodynamic data was acquired through determination of van't Hoff enthalpy of solution, enthalpy of fusion, and melting temperature. Indications of polymorphic enantiotropy were found primarily through solubility analysis and FTIR-ATR. A comprehensive thermodynamic investigation disclosed correlation between the van't Hoff enthalpy of solution and the solubility in different solvents. A higher solubility is linked to a lower van't Hoff enthalpy of solution. A thermodynamic analysis to discriminate between different solid phases is presented.
ISSN:0022-3549
DOI:10.1002/jps.20569