Genetic susceptibility to periodontitis

• Published in: Periodontology 2000 Vol. 58; no. 1; pp. 37 - 68
• Main Authors: Laine, Marja L., Crielaard, Wim, Loos, Bruno G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-02-2012
• Subjects: Aggressive Periodontitis - genetics; Alleles; Chronic Periodontitis - genetics; Dentistry; Genetic Linkage - genetics; Genetic Predisposition to Disease - genetics; Humans; Polymorphism, Genetic - genetics; Research Design
• ISSN: 0906-6713; 1600-0757
• DOI: 10.1111/j.1600-0757.2011.00415.x

In this systematic review, we explore and summarize the peer‐reviewed literature on putative genetic risk factors for susceptibility to aggressive and chronic periodontitis. A comprehensive literature search on the PubMed database was performed using the keywords ‘periodontitis’ or ‘periodontal disease’ in combination with the words ‘genes’, ‘mutation’, ‘SNP’ or ‘polymorphism’. The studies selected were written in English, had a case–control design, and reported genotype distribution. Only studies with at least 100 individuals in either the case or control group were included. Research on genetic polymorphisms has only had limited success in identifying significant and reproducible genetic factors for susceptibility to aggressive periodontitis and chronic periodontitis. Taking together the data published on gene polymorphisms in aggressive and chronic periodontitis, we conclude that there are differences among the various studies for the rare allele carriage rates. Nevertheless, there is some evidence that polymorphisms in the IL1B, IL1RN, FcγRIIIb, VDR and TLR4 genes may be associated with aggressive periodontitis susceptibility, and polymorphisms in the IL1B, IL1RN, IL6, IL10, VDR, CD14, TLR4 and MMP1 genes may be associated with chronic periodontitis susceptibility as a single genetic factor in certain populations. Future studies should apply stricter disease classifications, use larger study cohorts, adjust for relevant risk factors in aggressive and chronic periodontiti,s and include analysis of multiple genes and polymorphisms. Establishing consortia and performing collaborative studies may help to conquer the limitations of small sample size and limited statistical power.